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For negative mode acquisition, mobile phase A was 100% LC-MS grade H 2 O with 10 mM ammonium acetate, 0.1% ammonium hydroxide, and 0.1, 100% B

Front Microbiol 9:647

Furthermore, the use of CRO has been shown to markedly decrease total tau protein levels and phosphorylation, suppresses - and -secretase activities, and reduces the deposition of A precursor protein (APP) accumulation in AD models by inhibiting ERK1/2 kinase activity (Rashedinia et al., 2015)