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196 In summary, a reciprocal regulatory loop exists between BMAL1 and HIF-1, wherein BMAL1 modulates both the activity and transcription of HIF-1, while HIF-1 in turn regulates BMAL1 expression and circadian rhythm

[5] Hence SAM synthetase is fast becoming a drug target, in particular for the following diseases: depression, dementia, vacuolar myelopathy, liver injury, migraine, osteoarthritis, and as a potential cancer chemopreventive agent

doi: 10.1084/jem.20110698 21 WongAWXiaoJKemperDKilpatrickTJMurraySS

Through molecular docking experiments, we determined that the binding energy between ANH and ACSL4 was -8.7 kcal/mol (Fig