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In this regard, until recently, glutathione could only be effectively taken by injection: the oral route has always been a strong limit for its absorption, so much so as to be practically discarded

The disease is caused by a mutation in the ATP7B gene, which codes for a protein that facilitates the incorporation of copper into proteins (such as ceruloplasmin) and also the transportation of copper into vesicles that allow it to be secreted in bile.1 The critical effect of a mutation in ATP7B is diminished copper secretion into bile, which leads to excess copper accumulation in the hepatocyte

doi: 10.1177/1479164114521643 84 AlsawafSAlnuaimiFAfzalSThomasRMChelakkotALRamadanWSet al

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