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The survival and migration of neural stem cells were also reported to be regulated by IGF-1R when transplanted into an injured spinal cord, and their survival and migration could be augmented through treadmill training (Hwang et al., 2018)

Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Goncalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV (2017) Adenosine A2A receptors modulate alpha-synuclein aggregation and toxicity

They propose a staging system that takes into account these anchors, and starts from Stage 0, preclinical disease, defined by the presence of fully penetrant SNCA variants

Kerr S-L, Mathew C, Ghildyal R (2021) Rhinovirus and cell death