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Moreover, the number of Bifidobacterium and Lactobacillus in their feces was significantly reduced, which induced a decrease in the proportion of Bifidobacterium to Enterococcus ( P = 0.03), and 6 months of ursodeoxycholic acid (UDCA) treatment significantly increased the diversity and abundance of gut microbiota, thereby alleviating PBC progression, which indicates a nonnegligible role for modulating gut microbiota in PBC treatment ( Veillonella genera increases with the severity of PSC, suggesting the important role of gut microbiota and its metabolites in the prevention and treatment of PSC ( In view of the unignorable or noticeable roles of various gut microbiota in the progression of AILD, it is of great significance to explore TCMs and NPs targeting gut microbiota for AILD research and treatment, as shown in Table 1

doi: 10.1089/ars.2012.4645 34 MaZBiQWangY