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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

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It's primarily found in the liver, where it might help neutralizes harmful substances and detoxifies the body, but it also has other important functions.* Its antioxidant properties may help protect cells from damage by neutralizing harmful free radicals and reactive oxygen species produced during metabolic processes.* Moreover, it may help bolster the immune system, helps maintain the active forms of other essential antioxidants such as vitamins C and E, and promote DNA synthesis and repair.* One of the most unique features of L-Glutathione lies in the sulfur (SH) groups it contains

Sarris AH, Kliche KO, Peethambaram PP, Witzig T, Andreeff M , Cabanillas F