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Microbiota-derived metabolites may drive changes in barrier integrity, as mono-colonization with specific short-chain fatty acid (SCFA)-producing bacteria such as Clostridium tyrobutyricum DSM 2637 (butyrate-producing) or Bacteroides thetaiotaomicron (acetate and propionate producing) in GF mice protect from BBB permeability [85]

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J Herbal Med 46:100896 Braga PC, Culici M, Alfieri M, Dal Sasso M (2008) Thymol inhibits Candida albicans biofilm formation and mature biofilm

Addressing the gaps in knowledge in each of these areas is critical: future research needs to prioritize conducting IV studies to definitively calculation bioavailability, also followed by thoroughly testing novel formulation approaches (for example,