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Mechanistically, Hedgehog binding to the transmembrane protein patched (PTC) induces the activation of smoothened (SMO), which stimulates the expression of downstream genes such as Ccnd1 via zinc finger transcription (GLI) factors

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Virus-induced hyper-inflammation with complement activation in kidney tissue could inflict focal segmental glomerulo-sclerosis with glomerular involution and lead to AKI 138