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In animal models of diet-induced obesity, co-administration of cagrilintide and semaglutide produced additive suppression of food intake, greater fat mass loss, and improved metabolic markers beyond what either compound achieved alone

Furthermore, stimulation has recently been shown to be associated with increased neurogenesis in the perilesional cortex, as well as in the mediodorsal and ventrolateral thalamic relay nuclei, providing another mechanism through which the facilitative effects of stimulation may occur

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