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Rintatolimod: toll-like receptor 3 (TLR3) agonist for ME/CFS therapy By activating TLR3, rintatolimod triggers a type I interferon-mediated antiviral response, which upregulates effector proteins such as 2-5 oligoadenylate synthetase and protein kinase R to degrade viral ribonucleic acid (RNA) and inhibit translation, collectively enhancing the hosts antiviral defense