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[2] Amphetamine is eliminated via the kidneys, with 3040% of the drug being excreted unchanged at normal urinary pH

This hypothesis is consistent with our results showing that curcumin binds to several enzymes functioning in the ROS metabolic pathway and regulating intracellular ROS levels, which trigger p53-dependent and -independent checkpoint pathways, resulting in apoptosis or senescence 23,24,25,26,27

Disease: Evidence suggests that disease states generally have a negative effect on drug metabolism capacity