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10.1038/nature11133 Aisen P, Listowsky I ( 1980 )

A few times weekly at moderate concentrations, year after year, keeps the remodelling signals steady and the MMP/TIMP balance intact

The study posits that DSIP's actions on substance P, beta-endorphin, and corticosterone levels are part of a broader spectrum of biochemical changes, hinting that DSIP might initiate a series of molecular reactions contributing to its stress-modulatory actions