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Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease

Grx2 was identified a little over a decade ago, shares ~34% sequence identity with Grx1, and is highly concentrated (~1 M in comparison to Grx1 which is ~0.1 M) in mitochondria (Gallogly et al., 2004)

Similarly, lipid or protein exchange probability is not high as it occurs when liposomes contain proteins that facilitate lipid exchange with lipoprotein included into the cell membrane [15]

However, about 10-15% of acetaminophen is metabolized by CYP2E1 into a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine).[ref] Detoxification with glutathione: NAPQI then needs to be neutralized with glutathione, which is catalyzed using the GST genes