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Moreover, FA-induced enhancement of the GSH system attenuated lipid peroxidation and prevented cardiac ferroptosis mediated by I/R [41]

Mitochondria are responsible for cardiomyocyte death through necrosis and apoptosis in ischaemia/reperfusion 62 , both initiated by the disintegration of mitochondrial membranes

Indeed, specific BAs are increasingly implicated in sculpting immunosuppressive pre-metastatic niches, thereby facilitating distant metastasis in cancers like HCC and CRC (172)

Abstract Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies