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Individuals at risk of vitamin B12 deficiency include older adults, people with gastrointestinal disorders, those who have had gastrointestinal surgeries, individuals on a strict vegan diet, individuals who take metformin for blood sugar control, and people taking proton pump inhibitors for chronic heartburn

Cerebral metabolic changes in biotinidase deficiency

The relative numbers of fibers with an EdU + myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively

Furthermore, as patients on B12 therapy were excluded from the study and intestinal absorption capacity for B12 is limited, they hypothesized that elevated levels are directly related to malignization