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These include:[ref] Inflammatory cytokines (IL-1B, IL-33), which cause the release of IL-6, TNF, IL-8, and VEGF Heavy metals (aluminum, cadmium, mercury) Herbicides (atrazine, glyphosate) Pathogens (Lyme disease, lipopolysaccharides from bacteria, certain viruses, and mold spores) These triggers can cause a two-phase reaction : Immediately released mediators include histamine, TNF, tryptase, RANKL, and serotonin

J Neurochem 114:820831 Shinohara M, Saitoh M, Takanashi J, Yamanouchi H, Kubota M, Goto T, Kikuchi M, Shiihara T, Yamanaka G, Mizuguchi M (2011) Carnitine palmitoyl transferase II polymorphism is associated with multiple syndromes of acute encephalopathy with various infectious diseases

The results indicated a statistically significant reduction in melanin indices at certain sites compared to a placebo group, suggesting that oral glutathione may have a measurable effect on skin tone

In a clinical trial of AIDS patients were treated with 1.8 g/day of NAC for two weeks with the glutathione status monitored in plasma and lymphocytes