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Fluorescence images were obtained with confocal microscope Nikon A1Rsi (Nikon, Germany) microscope with Plan Plan Apo 10x/0.45 DIC N1, Plan Apo VC 20x/0.75 DIC N2, Apo 40x/1.25 WI S DIC N2, Plan Apo VC 60x/1.4 Oil DIC N2 and Plan Apo VC 100x/1.4 Oil DIC N2 lenses and with Nikon NIS Elements AR 5.21.01 64-bit software (Nikon, Germany) or with confocal microscope LEICA Stellaris 8 (Leica Camera, Germany) with HC PL APO 20x/0.75 CS2 Air, HC PL IRAPO 40x/1.10 W CORR, PL APO 63x/1.20 W CORR CS2 or PL APO 63x/1.20 W CORR CS2 lenses and with Leica LAS X Office 1.4.7 64-bit software (Leica Camera, Germany) or with light sheet fluorescence microscopy (LSFM) ZEISS Lightsheet 7 (Zeiss, Germany) with W Plan-APO 20x/1,0 DIC lens, in water chamber and with ZEN Black 3.1 software for imaging and ZEN Blue 3.1 software for data analysis (Zeiss, Germany)

Multiple studies have shown that this therapeutic resistance can be reversed by direct targeting of SLC7A11 (9092)

Mitochondrial regulation of the tumor microenvironment Mitochondria are central to the dynamic interplay between cancer cells and the various immune populations that infiltrate the TME

It is not a dermal filler and should not be positioned as a product for volume restoration