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In the heart and kidneys, the reduction in SIRT1 expression and the systemic or local effects of angiotensin II may be significant factors in the development of hypertension (Yeganeh-Hajahmadi et al., 2021)

Population variability, as indexed by the F-value, was significantly greater in the ASD group as compared with the control group for all biochemical markers of mitochondrial dysfunction except ubiquinone, with the difference particularly marked for pyruvate