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Although this is consistent and mechanistically validated across different preclinical models, as reviewed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section, the correspondence between NAD + changes and mitochondrial or metabolic alterations is more complex in human studies

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As the hallmark roles for TrxR are to provide reducing power for RNR and antioxidant enzymes, one might first ask whether the metazoan transition was associated with novel replication- or antioxidant-demands, which might have been better served by the new TrxR

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