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Frias JP, Deenadayalan S, et al

Animal studies and observations in acromegalic patients demonstrate that GH-excess can have deleterious effects on kidney health, including glomerular hyperfiltration, renal hypertrophy, and glomerulosclerosis

In this context, Everolimus is a promising second-generation rapamycin derivative and is a specific inhibitor of mTORC1, which suppress mRNA translation, ribosome biogenesis, protein synthesis, mitochondrial metabolism, and adipogenesis 83

It was observed that treatment with ALA led to a stabilization of cognitive functions demonstrated by constant scores in two neuropsychological tests (the Mini-Mental State Examination and the cognitive subscale of the AD assessment score)