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In particular, hydrogen peroxide (H 2 O 2 ) has been implicated as a marker for human ovarian ageing 32 and an increase in free-radical activity has been correlated with a decrease in, in vitro fertilisation (IVF) success rates 33

Figure 1 Recently, we measured some parameters of adenine nucleotide metabolism, glycolysis, pentose phosphate pathway, 2,3-DPG shunt (Kaminsky et al., 2013), oxidant and antioxidant enzymes and metabolites (Kosenko et al., 2012) in RBCs samples from Alzheimer's subjects (AD) and non-Alzheimer's dementia (NA) patients

Bioengineered 12(2):1255512567

These disorders not only significantly reduce the quality of the patients sexual life, but also have a detrimental impact on fertility