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These results showed that the highest number of a total of 159 differentially expressed miRNAs were revealed in the LRM group, while the TPL, LRSH, and TPH groups showed relatively smaller numbers of differentially expressed miRNAs of 60, 115, and 120, respectively (Figure 3A)

A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)