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These physiological processes prevent oral doses from resulting in therapeutic plasma concentrations sufficient for significant antioxidant effects in tissues, and low solubility combined with rapid metabolism reduces the time in which the antioxidant remains in its active form, compromising its efficacy in chronic diseases that require sustained action [57, 58]

This was achieved using the Matlab scripts given in the supplementary software of the Tsigkinopoulou et al protocol

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[32] MDMA has limited approved medical uses in a small number of countries, [33] but is illegal in most jurisdictions