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Several different types of biologics target different proteins, such as: Tumor necrosis factor (TNF) inhibitors TNF is a protein some of your immune system cells (called macrophages) make, and it causes inflammation

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Moreover, inflammatory form as pyroptosis, of programmed cell death, has been implicated in liver diseases, where caspase-1 activation triggers membrane rupture, inflammatory cytokine release, and exacerbated tissue damage 4 Furthermore, inflammasomes, including the NLRP3 ((NOD-, LRR-, and pyrin domain-comprising protein 3), have been concerned in liver diseases, where activation of this complex triggers caspase-1 activation, promoting pyroptosis and inflammatory cytokines release such as IL-1 and IL-18, further exacerbating liver damage 5