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Vitamin B12 Folate Deficiency Anaemia Vitamin B12 or B9 (commonly called folate) deficiency anaemia occurs when a lack of vitamin B12 or folate causes the body to produce abnormally large red blood cells that cannot function properly

3 In the current work, an optimized manufacturing process with improved transduction efficiencies was achieved, with mean vector copy number (mVCN) in peripheral blood 24 months after treatment of 1.992 (0.153.49, n = 16) in patients who became transfusion-independent, as compared to mVCN of 0.7 (0.31.5, n = 18) in HGB-204 and 1.3 (0.82.1, n = 4) in HGB-205

The activity of PNPO is essential for the synthesis of PLP, which is the only theoretically effective therapeutic agent, and must be taken every 6 hours

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