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It is also noteworthy that metabolic dysfunction in CD8+ T cells, driven by the immunosuppressive microenvironment of chronic lymphocytic leukaemia (CLL), contributes to CAR-T therapy resistance (Van Bruggen et al, 2019)

Interplay of m(6) A and histone modifications contributes to temozolomide resistance in glioblastoma

[DOI] [PubMed] [Google Scholar] 17.Pickart L, Vasquez-Soltero JM, Margolina A

The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/akt and NF-kappaB-inducing kinase pathways: Role of H(2)O(2) in NF-kappaB activation