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MI involves mentally rehearsing movements without physical execution, and its neural substrates exhibit substantial overlap with the motor execution network (Bai et al., 2020)

Importantly, however, particle design governs risk: surface-displayed antigens or certain chemistries can raise immunogenicity and, in rare cases, provoke severe hypersensitivity (including anaphylaxis), whereas encapsulation strategies tend to blunt immediate antigen recognition and are therefore often safer in vivo (206, 208)

Rouar, T., Parik, P., Kucera, O., Barto, M

However, direct clinical evidence demonstrating this causal sequence in patients remains limited and warrants further validation using in vivo or ex vivo barrierfunction assays