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Lipid-based DDSs (LBDDSs) utilize phospholipid bilayer architectures [e.g., liposomes, ethosomes, and solid lipid nanoparticles (SLNs)] to achieve localized drug enrichment in joint cavities or inflammatory foci, with reduced immunogenicity due to biomimetic membrane properties (Seo et al., 2023)

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doi: 10.1016/j.bbi.2021.12.020

Once established, large, randomized, placebo-controlled trials are needed to determine the effect of SFN on long-term outcomes such as disease progression and mortality in patients with CKD, and whether the effect is modified by genetics in a precision medicine approach