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Published online September 9, 2024

The resulting almost clear solution is applied on a column of AmberliteIRl20H ion-exchange resin (Rohm & Haas), and then on Resindion SepabeadsSP207 resin (Mitsubishi), and finally concentrated by nanofiltration, as described in paragraphs [0060] and [0061] of said patent

Key Takeaway: NAC acts as a primary building block for glutathione by providing cysteine, which is typically the scarcest amino acid required for the body to manufacture its own antioxidant supply

352 , 353 , 354 It is notable that these misfolded proteins may spread from the intestine to the CNS through the vagus nerve pathway, a process that is consistent with the Braak hypothesis on the pathological development of PD, namely, that the pathological changes of -synuclein may start in the intestine and then spread to the brain in a prion-like manner