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A similar problem was reported in Chile where 100 000 people consumed drinking-water containing 800 g As/litre between 1959 and 1970, when the concentration was lowered to about 50 g/litre(Borgono et al., 1977)

Genome-wide significance A statistical threshold ( P = 5 10 8 ) based on the testing of one million single-nucleotide polymorphisms in a genome-wide association study and on the use of a Bonferroni correction for multiple testing (that is, 0.05/1,000,000)