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A recent study showed that glucose metabolism was dysregulated and that pyruvate supplementation could prevent neurodegeneration in an animal model of glaucoma 31 , suggesting that ATP production from glycolysis is disrupted, and that other energy fuel pathways, such as -oxidation, may be augmented to compensate for the reduction in energy metabolism

We expect that more potent inhibitors, perhaps based on the 2P-AC scaffold, would provide good starting points for drug development and further validation of SapM as a drug target

Melanocortin peptides in inflammation modulation.Pharmacology & Therapeutics(2006)

R., Liles, L