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The shRNA constructs against NRF2 were designed targeting guggcugcucagaauugcaga (sh NRF2 -1), guaagaagccagauguuaaga (sh NRF2 -2), and gcuccuacugugaugugaaau (sh NRF2 -3) (#230086 and 230087, Addgene)

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In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Costabile et al., 2017)

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