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In support of this, the transcriptional reprogramming score of cells poised to reprogram 48 was improved by B 12 supplementation (Extended Data Fig

doi: 10.1038/s41388-022-02460-1 83 KlassonTDLaGoryELZhaoHHuynhSKPapandreouIMoonEJet al

doi: 10.1002/advs.202300286 250 DingQTangWLiXDingYChenXCaoWet al

Malabsorption (insufficient absorption of vitamin B12in the intestine) through, Insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and isrequiredfor the absorption of vitamin B12), Diseases in the terminal segment of the ileum (part of the small intestine), e.g