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Description

10.1038/mp.2016.189 114 KaushikR.MorkovinE.SchneebergJ.ConfetturaA

Uniquely, it had a time period at the end of the study where study medication was discontinued for 12 weeks, then reassessed to see if the treatment effects persisted

Since its identification, over 28,000 research papers have described its relevance to several inborn errors of metabolism, B vitamin status, and diseases as diverse as cardio- and cerebrovascular disease, dementia, renal disease, thyroid disease, and pregnancy complications, to name but a few