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While evidence supporting the vascular normalization theory has been accumulating over the past decade, questions still remain

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Cardiac fibrosis establishes a permissive AF substrate Cardiac fibrosis, a hallmark of structural remodeling, promotes pathological changes predominantly in the atria in AF, providing a substrate for AF by increasing conduction heterogeneity and stabilizing reentrant circuits

[3] Cell Line:Primary cortical neurons Concentration:1 and 5 M Incubation Time:12, 24 and 48 hours Result:Enhanced the LC3-I conversion to LC3-II in a concentration-dependent manner at all analyzed time points