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Hinge like the angiotensin IV antagonist Norleual, was established as a c-Met antagonist by its ability to block HGF-dependent c-Met phosphorylation and prevent HGF-dependent scattering in the MDCK epithelial cell line

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Moreover, in agreement with the critical role of the capsule for meningococcal intracellular survival (Spinosa et al., 2007), siaD deletion in the MC58 strain led to an increase in adhesion to Calu3 LLI but to a strong reduction in intracellular bacteria and in transcellular crossing (Sutherland et al., 2010)