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However, since lactate is a metabolic byproduct and greater metabolic demand increases lactate production, the remaining muscle cells produce even more lactate than usual due to their increased workload, hastening the accumulation of lactate and exacerbating neuronal destruction and muscular atrophy

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Proper medical diagnosis is essential before treatment, as not all nerve pain stems from B12 deficiencydiabetes, autoimmune disorders, and other conditions cause similar symptoms

Besides, the majority of the durian trees have been planted for decades in natural hilly areas where an irrigation system is not necessary, as compared with modern orchards where trees are planted on man-made raised mounds with irrigation (Pinsorn and Sirikantaramas 2025)