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Thus, we hypothesized that PTX resistance could be transmitted from drug-resistant cells to sensitive cells via supernatant-mediated communication

Nanosized carriers are promising drug delivery systems for the brain [18, 19]

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The aggregation of proteins leads to the formation of highly ordered pathogenic fibrillar aggregates, called amyloid fibrils 19,20 , which are implicated not only in HCCAA but also in a wide range of neurodegenerative diseases such as Alzheimers, Parkinsons, CreutzfeldtJacobs, and Huntingtons disease 20