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[10] IP3 appears to bind to receptors on the endoplasmic reticulum, releasing calcium ions, while DAG may activate protein kinase C, phosphorylating signaling molecules and amplifying the cascade

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Recently, it has been reported that HCys upregulates platelet-derived growth factor levels by DNA de-methylation, affecting the cross-talk between endothelial cells and vascular smooth muscle cells (52)

However, it is important to note that these studies conducted much of their sampling in North America and Europe and there is a need to diversify sampling to other regions globally to capture different vaginal microbiota compositions 80