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Nociceptive pain reflects the normal functioning of the somatosensory systems responding in a stimulus-dependent manner to an actual or potential damage of non-neuronal tissue and is treated with conventional non-steroidal anti-inflammatory and/or opioid analgesics (Freynhagen et al., 2019)

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As is well-known, l-carnitine can adjust many events, such as metabolism of glucose and fatty acids, and has the potential to protect these cellular events in several manners including decreasing the production of reactive oxygen species at different points and maintaining mitochondrial functions (24)

Although some progress has been made in understanding the biological functions and potential mechanisms of the carnitine metabolism pool, their complexity and differences in pharmacology and pathophysiology still need to be further explored and understood