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PPA exposure produced pronounced oxidative stress and disruptions in lipid metabolism, whereas post-treatment with omega-3 or vitamin B12, administered individually or together, partially normalized antioxidant defenses, modulated inflammatory enzyme activity, and altered microbial profiles

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For Crystaline silica, for both the occupational low- and high-risk scenarios, the predicted lower respiratory exposure was higher than the minimum PoD from transcriptomics, but neither scenario led to exposures which exceed the minimum PoDs for other readouts

Specifically, they noticed a substantial decrease in the expression of lipogenic genes, including ACC , PPAR , and CPT-1a , following the administration of sodium butyrate therapy in comparison to the control treatment