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Having reviewed the main cereblon ligands incorporated in the construction of cereblon-based PROTACs, the synthetic routes for obtaining these degraders, and having analyzed the main results of their biological evaluation, it is still important to discuss and reflect on the current challenges that cereblon-based PROTACs still face, as well as their future prospects

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Formalin-fixed colonic samples were embedded in paraffin, and sections were stained with H&E