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Sulman EP, Chang JY , Liao Z, Guerrero TM, Jeter MD, Stevens CW, Cox JD, Komaki R

butyrate is predominantly utilized by colonocytes, with only small amounts entering systemic circulation ( de novo lipogenesis (DNL) ( When intestinal barrier function is compromised, bacterial components such as LPS can enter the liver via the portal vein, triggering Toll-like receptor 4 (TLR4)-mediated inflammatory responses ( 3.2.2 Hepatic processing and distribution of gut-derived metabolites The liver, as the body's largest metabolic organ, possesses robust capabilities for substrate extraction and biotransformation

Specifically, at day 7, there is an infiltration of inflammatory cells while controls presented prominent edema, disintegrated reticulin fiber network, and no proliferation of collagen fibers (Figure 9 and Figure 10), and reduction of capillaries with survived arterioles of the myotendinous junction

Statistical analyses were performed using GraphPad Prism 9 software (La Jolla, CA, USA)