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In OA, elevated ROS levels contributed to inflammatory cytokines overproduction, reduced synthesis of extracellular matrix (ECM), and enhanced chondrocyte apoptosis, which collectively promotes cartilage degradation 5,10

The question remains whether early intervention improves outcomes in such patients or leads to adverse effects due to unnecessary treatment

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The kratom indole alkaloids speciociliatine, speciogynine, mitraciliatine, paynantheine, and isopaynantheine were isolated and purified from commercial kratom products as described 3,5