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The persistence of symptoms despite TNF inhibition suggests that effective intervention requires a multi-target approach addressing epithelial stability and ROS signaling rather than inflammation alone

First, ferroptosis shapes the TME in ways that promote immune suppression and tumor progression

J Cutan Pathol (1993) 20(3):193202

These defects are often transmitted as autosomal recessive traits and may be expressed at any one of the multiple metabolic transformations that a chemical might undergo