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doi: 10.4110/in.2018.18.e11 121 MarschangPSodroskiJWrznerRDierichMP

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These exceptionally large repeat expansions demonstrate striking cellular specificity, being predominantly localized to MSNs ( Genome-wide association studies have identified potential genetic modifiers, including mismatch-repair (MMR) genes ( MSH3 , MLH1 , PMS1 and PMS2 ) and other DNA repair genes ( FAN1 and LIG1 ) ( MSH3 , PMS1 , MSH2 and MLH1 ) ameliorates both early-onset phenotypes in MSNs and late-onset manifestations in cortical neurons, including somatic CAG-repeat expansion, transcriptionopathy and mHTT aggregation ( MSH3 deficiency specifically improves open-chromatin dysregulation in neurons

Dosis recomendada: Tomar 1 a 2 ml o goteros al da directamente bajo la lengua, preferentemente en ayunas para una mejor absorcin