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J Inflammation Res (2020) 13:51931

ERK1/2 and NF-B signaling are two ways in which IL-17 can increase IL-8 expression [156, 157]

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[0344] Thus, one or more structural features of an anti-ALPP/ALPPL2 antibody, such as the CDRs, can be used to create structurally related anti-ALPP/ALPPL2 antibodies that retain at least one functional property of, for example, the M25 ADLF, M25 ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25 ASwt, M25 AVIA, M25AVLF, M25 ALIA, M25ALLF, M25wtIA, and/or M25wtLF antibody, e.g., binding to tumor cells that express ALPPL2