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Description

Int J Biol

Gut Microbes 13 , 121 (2021)

As feedback mechanisms maintain the hormonal levels, the increased serum concentration of growth hormone (GH) stimulates another endogenous hormone called somatostatin, also known as growth hormone inhibiting hormone (GHIH)

While microbes and their products can breach the intestinal epithelium during normal cellular processes including luminal antigen sampling, dead cell extrusion, or programmed cell death, their systemic spread is restricted by specialised immune cells residing within the underlying lamina propria (Smith et al