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In most cell types, arginine can be synthesised through the activity of argininosuccinate synthetase (ASS1) and argininosuccinate lyase (ASL), their combined activities transferring the amino group of aspartate to convert citrulline into arginine

Palliative chemotherapy is administered without curative intent, but rather to prolong life and/or relieve symptoms

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using S-adenosyl methionine (SAM)

A randomised controlled trial testing the feasibility and efficacy of a physical activity behavioural change intervention in managing fatigue with gynaecological cancer survivors