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Reversed-phase (RP) HPLC typically uses octadecyl silica (C18) columns in combination with acidic mobile phases, composed of acetonitrile/water [32, 41,42,43], with additives like formic acid (FA) [41, 43, 45, 46], ammonium formate [42, 45, 47, 48], acetic acid (AcA) [49], ammonium acetate [32, 50], trichloroacetic acid (TCA) [38, 51], trifluoroacetic acid (TFA) [32, 50, 52], or ammonium phosphate [53]

DEG analysis of early-stage tumor cells showed that, compared to low- and high-mutant tumor cells, moderate-mutant tumor cells significantly upregulated genes encoding cytosolic ribosomal proteins (RPL and RPS), mitochondrial ribosomal proteins (MRPL and MRPS), and OXPHOS-related proteins (Fig

In the asymptomatic phase (4 months of age), the PINK1 knockout rat model has already exhibited mitochondrial dysfunction-related changes such as metabolic abnormalities, complex I activity-related alterations, and changes in oxygen consumption (196)

We believe the estimated burden for both patient screening and data submission would be the same for PCHs